Integra LifeSciences Holdings Corporation develops, manufactures, and markets surgical implants and medical instruments for neurosurgery, extremity reconstruction, orthopedics, and general surgery. Its orthopedics products include specialty metal implants; orthobiologic products for repair and grafting of bone; dermal regeneration products and tissue-engineered wound dressings; nerve and tendon for the peripheral nerve repair and protection, and tendon repair; and bone and joint fixation devices and instruments, and bone graft substitutes for extremity reconstruction. The companyís spine products comprise spinal fusion technologies; thoracolumbar fusion devices; cervical fusion devices; interbody fusion devices; motion preservation technologies; deformity correction; orthobiologic products, such as demineralized bone products, collagen ceramic matrices, and pure synthetic bone grafting solutions; and minimally invasive solutions to reduce blood loss and recovery time. Its neurosurgery products include dural repair products that are alternatives to tissue being removed and grafted from another location in the patientís body; cerebral spinal fluid management devices for use in abdominal aortic aneurysm surgery; tissue ablation equipment for the ablation of unwanted tissue; intracranial monitoring equipment for monitoring intracranial pressure and brain tissue oxygenation; and cranial stabilization equipment for neurosurgery procedures. The companyís instruments product portfolio comprises specialty and general surgical, and dental instruments and surgical lighting for sale to hospitals and outpatient surgery centers, as well as physician, veterinarian, and dental practices. It sells its products directly through various sales forces and distribution channels worldwide. Integra LifeSciences Holdings Corporation was founded in 1989 and is headquartered in Plainsboro, New Jersey.