Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery and development of treatments for human disease. Its portfolio of drug programs in various stages of clinical development include LX4211, a dual inhibitor of sodium-glucose cotransporters 1 and 2, which is in Phase IIb clinical trials for the treatment of type 2 diabetes; LX1032, an inhibitor of tryptophan hydroxylase, is preparing for Phase III registrational trials to reduce peripheral serotonin production without affecting brain serotonin levels in patients with carcinoid syndrome, as well as initiated a Phase II proof-of-concept trial for patients with ulcerative colitis; and LX1033, a serotonin synthesis inhibitor that is in Phase II clinical trials for the treatment of irritable bowel syndrome. The company also develops LX2931, an inhibitor of sphingosine-1-phosphate lyase, which completed a Phase IIa clinical trials and conducting a dose-ranging study to explore higher doses as a treatment for rheumatoid arthritis and other autoimmune diseases; and LX7101, an orally-delivered small molecule compound that initiated a Phase I-II proof-of-concept study in glaucoma patients. It also has advanced small molecule compounds from various additional drug programs into various stages of preclinical development and research. The company has drug discovery and development collaborations with Bristol-Myers Squibb Company; Genentech, Inc.; Schering-Plough/Organon; and Takeda Pharmaceutical Company Limited. Lexicon Pharmaceuticals, Inc. was founded in 1995 and is headquartered in The Woodlands, Texas.