Protalix BioTherapeutics, Inc., a biopharmaceutical company, through Protalix Ltd., focuses on the development and commercialization of recombinant therapeutic proteins based on its proprietary ProCellEx protein expression system in the United States. The company’s lead product candidate includes taliglucerase alfa, a proprietary plant cell expressed recombinant Glucocerebrosidase enzyme for the treatment of Gaucher disease, which has completed Phase III clinical trial. It is also developing PRX-102, a therapeutic protein candidate for the treatment of Fabry disease, a rare genetic lysosomal disorder in humans; PRX-105, a plant cell expressed pegylated recombinant acetylcholinesterase product candidate for biodefense and other indications; and PRX-106, a plant cell expressed recombinant fusion protein made from the soluble form of the human TNF receptor and an antibody portion, which is developed as a treatment of various immune diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, spondylitis, psoriatic arthritis, and plaque psoriasis. The company’s product pipeline also includes an orally-administered glucocerebrosidase enzyme for the treatment of Gaucher disease patients utilizing oral delivery of the recombinant enzyme produced within carrot cells; and two additional undisclosed therapeutic proteins, which are being evaluated in animal studies. It has a collaboration and licensing agreement with Teva Pharmaceutical Industries Ltd. to develop and manufacture two proteins using its ProCellEx protein expression system; and research and license agreement with the Yeda Research and Development Company Limited to design Glucocerebrosidase for the treatment of Gaucher disease. Protalix BioTherapeutics, Inc. was founded in 1993 and is based in Carmiel, Israel.